The Cochlear Amplifier: Is it Hair Bundle Motion of Outer Hair Cells?
نویسندگان
چکیده
منابع مشابه
Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.
There is current debate about the origin of mechanical amplification whereby outer hair cells generate force to augment the sensitivity and frequency selectivity of the mammalian cochlea. To distinguish contributions to force production from the mechanotransducer (MET) channels and somatic motility, we have measured hair bundle motion during depolarization of individual outer hair cells in isol...
متن کاملCochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.
Epithelial cells acquire diverse shapes relating to their different functions. This is particularly relevant for the cochlear outer hair cells (OHCs), whose apical and basolateral shapes accommodate the functioning of these cells as mechano-electrical and electromechanical transducers, respectively. We uncovered a circumferential shape transition of the apical junctional complex (AJC) of OHCs, ...
متن کاملActive hair bundle movements and the cochlear amplifier.
The "active process" is a term used to describe amplification and filtering processes that are essential for obtaining the exquisite sensitivity of hearing organs. Understanding the components of the active process is important both for our understanding of the normal physiology of hearing and because perturbations of the cochlear amplifier may lead to such maladies as threshold shifts (both te...
متن کاملAcetylcholine, outer hair cell electromotility, and the cochlear amplifier.
The dominant efferent innervation of the cochlea terminates on outer hair cells (OHCs), with acetylcholine (ACh) being its principal neurotransmitter. OHCs respond with a somatic shape change to alterations in their membrane potential, and this electromotile response is believed to provide mechanical feedback to the basilar membrane. We examine the effects of ACh on electromotile responses in i...
متن کاملMechanisms of active hair bundle motion in auditory hair cells.
Sound stimuli vibrate the hair bundles on auditory hair cells, but the resulting motion attributable to the mechanical stimulus may be modified by forces intrinsic to the bundle, which drive it actively. One category of active hair bundle motion has properties similar to fast adaptation of the mechanotransducer channels and is explicable if gating of the channels contributes significantly to th...
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ژورنال
عنوان ژورنال: Journal of Otology
سال: 2014
ISSN: 1672-2930
DOI: 10.1016/s1672-2930(14)50017-7